Steady-state visual evoked potentials (SSVEPs), the brain response to visual flicker stimulation, have proven beneficial in both research and clinical applications. Despite the practical advantages of stimulation at high frequencies in terms of visual comfort and safety, high frequency-SSVEPs have not received enough attention and little is known about the mechanisms behind their generation and propagation in time and space. In this study, we investigated the origin and propagation of SSVEPs in the gamma frequency band (40-60 Hz) by studying the dynamic properties of EEG in 32 subjects. Using low-resolution brain electromagnetic tomography (sLORETA) we identified the cortical sources involved in SSVEP generation in that frequency range to be in the primary visual cortex, Brodmann areas 17, 18 and 19 with minor contribution from sources in central and frontal sites. We investigated the SSVEP propagation as measured on the scalp in the framework of the existing theories regarding the neurophysiological mechanism through which the SSVEP spreads through the cortex. We found a progressive phase shift from posterior parieto-occipital sites over the cortex with a phase velocity of approx. 8-14 m/s and wavelength of about 21 and 24 cm. The SSVEP spatial properties appear sensitive to input frequency with higher stimulation frequencies showing a faster propagation speed.Since the treatment window of thrombolytic therapy for stroke is limited, new therapy remains to be developed. We have recently developed low-intensity pulsed ultrasound (LIPUS) therapy to improve cognitive dysfunction in mouse models of vascular dementia and Alzheimer's disease. Here, we further aimed to examine whether our LIPUS therapy improves neurological recovery from ischemic stroke, and if so, to elucidate the mechanisms involved. In a mouse model of middle cerebral artery occlusion (MCAO), we applied LIPUS (32 cycles, 193 mW/cm2) to the whole brain 3 times in the first week (days 1, 3, and 5) after MCAO. We evaluated neurological functions using behavioral tests and performed histological analyses. Furthermore, to elucidate how LIPUS works within the injured brain, we also tested the effects of LIPUS in endothelial nitric oxide synthase (eNOS)-deficient (eNOS-/-) mice. In wild-type mice, the LIPUS therapy markedly improved neurological functions in the tightrope and rotarod tests at 28 days after MCAO. Histological analyses showed that the LIPUS therapy significantly increased the numbers of CD31-positive blood vessels in the perifocal lesion and doublecortin (DCX)-positive neurons in the ischemic striatum, indicating the angio-neurogenesis effects of the therapy. Importantly, these beneficial effects of the LIPUS therapy were totally absent in eNOS-/- mice. No adverse effects of the LIPUS therapy were noted. These results indicate that the LIPUS therapy improves neurological functions after stroke through enhanced neuro-angiogenesis in mice in vivo in an eNOS-dependent manner, suggesting that it could a novel and non-invasive therapeutic option for stroke.Sand flux is the key factor to determine the migration of sand dunes and the erosion to the surrounding environment. There are crescent-shaped sand dunes of various scales in the desert, and there are significant differences in spatial wind field and sand flux among them. However, due to the difficulty of monitoring, it is difficult to continuously observe the spatial wind field and sand flux around the larger crescentic dunes. On the basis of the Reynolds-Average Navier-Stokes (RA-NS) equation and the stress and sand flux model, the distribution of wind field and sand flux of a circular dune with a height of 4.2 m and a length of about 100 m during the four evolutionary periods of the evolution into a crescentic dune was simulated in this study. By comparing with the measured results, we verified that the closer to the leeward side, the more the simulated values of the velocity in wind field and sand flux were in line with the measured results. In order to further analyze the influence of the height of dune tom of the leeward side, so the wind velocity was small and the eddy currents behind the leeward side were more stable. https://www.selleckchem.com/products/stm2457.html The simulation results indicated that wind velocity was not the only reason for increasing the amount of sand flux, and the fluctuation of wind flow caused by turbulence could also stimulate the movement of sand particles on the ground.Pyroclastic density currents are ground hugging gas-particle flows that originate from the collapse of an eruption column or lava dome. They move away from the volcano at high speed, causing devastation. The impact is generally associated with flow dynamic pressure and temperature. Little emphasis has yet been given to flow duration, although it is emerging that the survival of people engulfed in a current strongly depends on the exposure time. The AD 79 event of Somma-Vesuvius is used here to demonstrate the impact of pyroclastic density currents on humans during an historical eruption. At Herculaneum, at the foot of the volcano, the temperature and strength of the flow were so high that survival was impossible. At Pompeii, in the distal area, we use a new model indicating that the current had low strength and low temperature, which is confirmed by the absence of signs of trauma on corpses. Under such conditions, survival should have been possible if the current lasted a few minutes or less. Instead, our calculations demonstrate a flow duration of 17 min, long enough to make lethal the breathing of ash suspended in the current. We conclude that in distal areas where the mechanical and thermal effects of a pyroclastic density currents are diminished, flow duration is the key for survival.A new method has been established and employed to create a random nanophotonic crystal (NPhC) structure without photolithography on the unpolished side of a single-side-polished sapphire substrate. This nano structure has potential use in enhancing the light-extraction efficiency (LEE) of deep ultraviolet light-emitting diodes (DUV-LEDs), and has never been built for DUV-LED applications before. Two mask layers in the nano scale (Au and SiO2) were used to create the NPhC and observed using scanning electron microscopy to have an average height of 400 nm and various sizes from 10 to 200 nm. Finally, a conventional DUV-LED and a DUV-LED device with NPhC were simulated using 2D Lumerical Finite-Difference Time-Domain (FDTD) for comparison. The results show that the LEE of the DUV-LED device with this NPhC integrated was significantly directly enhanced by up to 46% and 90% for TE and TM modes, respectively, compared to the conventional DUV-LED device. Thus, this NPhC is believed to be a new, key technique to enhance the LEE of DUV-LEDs.